Article

Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons

2024-02-29

Abstract excerpt

Mutation of the ATL1 gene is one of the most common causes of hereditary spastic paraplegia (HSP), a group of genetic neurodegenerative conditions characterised by distal axonal degeneration of the corticospinal tract axons. Atlastin-1, the protein encoded by ATL1 , is one of three mammalian atlastins, which are homologous dynamin-like GTPases that control endoplasmic reticulum (ER) morphology by fusing tubules...

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Literature Corpus work: dc46a97a-6f04-5944-bf70-cac0f5011042
DOI: 10.1101/2024.02.29.582512

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