Article

PGC-1α and PPARs cooperatively mediate photoreceptor neuroprotection in <i>rd1</i> mouse inherited retinal degeneration

2025-10-22

Abstract excerpt

Retinitis pigmentosa (RP) is a group of inherited diseases characterized by a primary rod photoreceptor dysfunction and progressive rod and cone cell death. Due to their very high energy demand, the degeneration of photoreceptors may be linked to insufficient energy supply or metabolic imbalance. Critical transcription factors that regulate metabolism such as peroxisome proliferator-activated receptors (PPARs) and...

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Literature Corpus work: 1642f1de-cbce-5dde-9ad5-7cd4dff6df13
DOI: 10.1101/2025.10.21.683632

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