Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptors.

Cell death & disease - 22 May 2014

Sahaboglu A, Tanimoto N, Bolz S, Garrido M G, Ueffing M, Seeliger M W, Löwenheim H, Ekström P, Paquet-Durand F

Abstract excerpt

Hereditary retinal degeneration (RD) relates to a heterogeneous group of blinding human diseases in which the light sensitive neurons of the retina, the photoreceptors, die. RD is currently untreatable and the underlying cellular mechanisms remain poorly understood. However, the activity of the enzyme poly-ADP-ribose polymerase-1 (PARP1) and excessive generation of poly-ADP-ribose (PAR) polymers in photoreceptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic Nucleotide Phosphodiesterases, Type 6
Share to Glycoside Hydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Degeneration

Share to Phosphodiesterase Inhibitors

Share to Photoreceptor Cells, Vertebrate

Share to Poly (ADP-Ribose) Polymerase-1

Share to Poly(ADP-ribose) Polymerases

Share to Tissue Culture Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 24853412
DOI: 10.1038/cddis.2014.208
PMCID: PMC4047865

Genes

PARP1
PARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptors.PMID 24853412Read ↗

PARP1 Gene Knock-Out Increases Resistance to Retinal Degeneration without Affecting Retinal FunctionSemantic proximity Read ↗

Excessive Activation of Poly(ADP-Ribose) Polymerase Contributes to Inherited Photoreceptor Degeneration in the Retinal Degeneration 1 MouseSemantic proximity Read ↗

Mutant Nmnat1 leads to a retina-specific decrease of NAD+ accompanied by increased poly(ADP-ribose) in a mouse model of NMNAT1-associated retinal degeneration.Semantic proximity Read ↗

Protein kinase G inhibition preserves photoreceptor viability and function in a new mouse model for autosomal dominant retinitis pigmentosaSemantic proximity Read ↗

Programmed Non-Apoptotic Cell Death in Hereditary Retinal Degeneration: Crosstalk between cGMP-Dependent Pathways and PARthanatos?Semantic proximity Read ↗

cGMP-PKG dependent transcriptome in normal and degenerating retinas: Novel insights into the retinitis pigmentosa pathology.Semantic proximity Read ↗

Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degenerationSemantic proximity Read ↗

TaqMan Multiplex qPCR Method to Genotype PARG Knockout Mice.Semantic proximity Read ↗

PGC-1α and PPARs cooperatively mediate photoreceptor neuroprotection in <i>rd1</i> mouse inherited retinal degenerationSemantic proximity Read ↗

Inherited retinal degeneration: T-type voltage-gated channels, Na <sup>+</sup> /Ca <sup>2+</sup> -exchanger and calpain-2 promote photoreceptor cell deathSemantic proximity Read ↗

PKG activity causes photoreceptor cell death in two retinitis pigmentosa modelsSemantic proximity Read ↗

PARG activity is required for cell death by parthanatosSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.