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Article

Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration

22 Dec 2016

Abstract excerpt

The enzyme poly-ADP-ribose-polymerase (PARP) mediates DNA-repair and rearrangements of the nuclear chromatin. Generally, PARP activity is thought to promote cell survival and in recent years a number of PARP inhibitors have been clinically developed for cancer treatment. Paradoxically, PARP activity is also connected to many diseases including the untreatable blinding disease Retinitis Pigmentosa (RP), where PARP...

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PMID: 28004814
DOI: 10.1038/srep39537

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