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PGC-1α Determines Light Damage Susceptibility of the Murine Retina

13 Feb 2012

Abstract excerpt

The peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) proteins are key regulators of cellular bioenergetics and are accordingly expressed in tissues with a high energetic demand. For example, PGC-1α and PGC-1β control organ function of brown adipose tissue, heart, brain, liver and skeletal muscle. Surprisingly, despite their prominent role in the control of mitochondrial biogenesis and oxidative...

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PMID: 22348062
DOI: 10.1371/journal.pone.0031272

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