Article

Stereochemistry of transient protein-protein interactions in a signaling hub: exploring G3BP1-mediated regulation of CFTR deubiquitination

2022-03-02

Abstract excerpt

Intrinsically disordered proteins (IDPs) can coordinate often transient or weak interactions with multiple proteins to mediate complex signals within large, reversible protein networks. Among these, the IDP hub protein G3BP1 forms protein complexes with Caprin1 and USP10, and the resulting control of USP10 activity plays an important role in a pathogenic virulence system that targets CFTR endocytic recycling. Howe...

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Literature Corpus work: 16306eb2-1302-5b17-bed2-94f8fedcf48e
DOI: 10.1101/2022.03.02.482667

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