Article
A Retinoic Acid:YAP1 signaling axis controls atrial lineage commitment
2024-07-12
Abstract excerpt
Vitamin A/Retinoic Acid (Vit A/RA) signaling is essential for heart development. In cardiac progenitor cells (CPCs), RA signaling induces the expression of atrial lineage genes while repressing ventricular genes, thereby promoting the acquisition of an atrial cardiomyocyte cell fate. To achieve this, RA coordinates a complex regulatory network of downstream effectors that is not fully identified. To address this g...
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Identifiers and source
- Literature Corpus work
- 1614b26f-a2d8-5481-b70f-74fb8ad698ec
- DOI
- 10.1101/2024.07.11.602981