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Article

Nr2f1a and Isl1 repress acquisition of epicardial identity in venous atrial cardiomyocytes.

Development (Cambridge, England) - 1 Jun 2026

Martin Kendall E, Fernandes Andrew T, Sayed Mohammed, Hanlon Margaret A, Fallon Samuel, Lim Hee-Woong, Waxman Joshua S

Abstract excerpt

Regulatory networks that maintain cardiomyocyte identity are not completely understood. Here, we have examined the relationship of the transcription factors Nr2f1a and Isl1, which, respectively, repress and promote pacemaker cardiomyocyte (PC) differentiation within the venous pole of zebrafish atria. Using zebrafish nr2f1a;isl1 mutants, we found that loss of Isl1 exacerbates the inability to maintain the atrial...

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Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42153456
DOI: 10.1242/dev.205396
PMCID: PMC13286355

Genes

PC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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