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Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools

3 Apr 2023

Abstract excerpt

Cardiogenesis relies on the precise spatiotemporal coordination of multiple progenitor populations. Understanding the specification and differentiation of these distinct progenitor pools during human embryonic development is crucial for advancing our knowledge of congenital cardiac malformations and designing new regenerative therapies. By combining genetic labelling, single-cell transcriptomics, and ex vivo...

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PMID: 37012244
DOI: 10.1038/s41467-023-36764-x

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