Article

Modeling uniquely human gene regulatory function in humanized mice

2019-12-12

Abstract excerpt

The evolution of uniquely human traits likely entailed changes in developmental gene regulation. Human Accelerated Regions (HARs), which include transcriptional enhancers harboring a significant excess of human-specific sequence changes, are leading candidates for driving gene regulatory modifications in human development. However, insight into whether HARs alter the level, distribution and timing of endogenous ge...

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Literature Corpus work: 160228a2-c88d-58cc-a94b-d898ae656de0
DOI: 10.1101/2019.12.11.873075

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