Article

Epitranscriptome analysis of NAD-capped RNA by spike-in-based normalization

2023-03-24

Abstract excerpt

<h4>ABSTRACT</h4> The hub metabolite, nicotinamide adenine dinucleotide (NAD), can be used as an initiating nucleotide in RNA transcription to result in NAD-capped RNA (NAD-RNA). NAD-RNA that intimately connects metabolite with gene expression can be developed as novel biomarkers for aging and disease. Epitranscriptome-wide profiling of NAD-RNAs involves chemo-enzymatic labeling and affinity-based enrichment; yet...

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Literature Corpus work: 15c91601-707c-5272-aa08-5c506b7b365a
DOI: 10.1101/2023.03.23.534034

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