Back to search

Article

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging

2017-11-17

Abstract excerpt

Mammals display wide range of variation in their lifespan. Investigating the molecular networks that distinguish long-from short-lived species has proven useful to identify determinants of longevity. Here, we compared the liver of long-lived naked mole-rats (NMRs) and the phylogenetically closely related, shorter-lived, guinea pigs using an integrated omic approach. We found that NMRs livers display a unique expre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
15c34e1f-db42-5921-acba-f960f0a9ece3
DOI
10.1101/220343
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Species comparison of liver proteomes reveals links to naked mole-rat longevity and human agingDOI 10.1101/220343
Species comparison of liver proteomes reveals links to naked mole-rat longevity and human agingSemantic proximity
Long-lived rodents reveal signatures of positive selection in genes associated with lifespanSemantic proximity
Naked mole rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestylesSemantic proximity
Transcriptomic approaches to understanding ageing and metabolism in rodentsSemantic proximity
Conserved and species-specific molecular denominators in mammalian skeletal muscle agingSemantic proximity
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.Semantic proximity
Multi-omics Analysis of Aging Liver Reveals Changes in Endoplasmic Stress and Degradation Pathways in Female Nonhuman PrimatesSemantic proximity
Targeting metabolic pathways for extension of lifespan and healthspan across multiple species.Semantic proximity
Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type <i>C. elegans</i> strainsSemantic proximity
The metabolic footprint of aging in miceSemantic proximity
The Naked Mole-Rat: A New Long-Living Model for Human Aging ResearchSemantic proximity
Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites and pathways that regulate lifespanSemantic proximity
Select a neighboring publication to make it the new centre.