Article

Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites and pathways that regulate lifespan

2023-01-27

Abstract excerpt

Altered mitochondrial function is tightly linked to lifespan regulation, but underlying mechanisms remain unclear. Here, we report the chronological and replicative lifespan variation across 168 yeast knock-out strains, each lacking a single nuclear-coded mitochondrial gene, including 144 genes with human homologs, many associated with diseases. We dissected the signatures of observed lifespan differences by analy...

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Literature Corpus work: 46f7b839-f0e7-5b98-8e1f-13398e9c0e33
DOI: 10.1101/2023.01.26.525799

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