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Article

Targeting metabolic pathways for extension of lifespan and healthspan across multiple species.

Ageing research reviews - 1 Dec 2020

Parkhitko Andrey A, Filine Elizabeth, Mohr Stephanie E, Moskalev Alexey, Perrimon Norbert

Abstract excerpt

Metabolism plays a significant role in the regulation of aging at different levels, and metabolic reprogramming represents a major driving force in aging. Metabolic reprogramming leads to impaired organismal fitness, an age-dependent increase in susceptibility to diseases, decreased ability to mount a stress response, and increased frailty. The complexity of age-dependent metabolic reprogramming comes from the...

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Identifiers

PMID: 33031925
DOI: 10.1016/j.arr.2020.101188
PMCID: PMC9038119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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