Article

SERPINB3 induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer

2023-04-01

Abstract excerpt

Pancreatic cancer is a heterogeneous disease with distinct subtypes. Here, we investigated candidate driver genes of the highly aggressive basal-like/squamous molecular subtype of pancreatic ductal adenocarcinoma (PDAC). Integrative transcriptomic analyses identified the upregulated serine/cysteine protease inhibitor, SERPINB3 (squamous cell carcinoma antigen 1, SCCA1) in basal-like/squamous PDAC using discovery a...

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Literature Corpus work: aa1731f9-6106-5276-9465-cac5f4901691
DOI: 10.1101/2023.03.29.534766

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