Article

Neuronal activity-regulated gene transcription: how are distant synaptic signals conveyed to the nucleus?

2012-12-19

Abstract excerpt

Synaptic activity can trigger gene expression programs that are required for the stable change of neuronal properties, a process that is essential for learning and memory. Currently, it is still unclear how the stimulation of dendritic synapses can be coupled to transcription in the nucleus in a timely way given that large distances can separate these two cellular compartments. Although several mechanisms have bee...

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Literature Corpus work: 69109aed-bdef-5ca7-b788-f9b51c1e35ac
DOI: 10.12688/f1000research.1-69.v1

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