Article

Functional overlap between the mammalian <i>Sar1a</i> and <i>Sar1b</i> paralogs in vivo

2024-02-29

Abstract excerpt

Proteins carrying a signal peptide and/or a transmembrane domain enter the intracellular secretory pathway at the endoplasmic reticulum (ER) and are transported to the Golgi apparatus via COPII vesicles or tubules. SAR1 initiates COPII coat assembly by recruiting other coat proteins to the ER membrane. Mammalian genomes encode two SAR1 paralogs, SAR1A and SAR1B . While these paralogs exhibit ∼90% amino acid seq...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 157886db-eb39-5696-8128-69bfd3ccb8e4
DOI: 10.1101/2024.02.27.582310

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functional overlap between the mammalian <i>Sar1a</i> and <i>Sar1b</i> paralogs in vivoDOI 10.1101/2024.02.27.582310Read

Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivoSemantic proximity Read

Animal model of Sar1b deficiency presents lipid absorption deficits similar to Anderson disease.Semantic proximity Read

SAR1 paralogs differ biochemically in assembly of the COPII coatSemantic proximity Read

The intracellular transport of chylomicrons requires the small GTPase, Sar1b.Semantic proximity Read

Sar1b mutant mice recapitulate gastrointestinal abnormalities associated with chylomicron retention disease.Semantic proximity Read

Loss of Serpina1 in Mice Leads to Altered Gene Expression in Inflammatory and Metabolic PathwaysSemantic proximity Read

Molecular analysis and intestinal expression of SAR1 genes and proteins in Anderson's disease (Chylomicron retention disease).Semantic proximity Read

Deletion of Serpina1a, a murine α1-antitrypsin ortholog, results in embryonic lethality.Semantic proximity Read

Loss of <i>asgr1a</i> leads to the secretion of excess dietary cholesterol in zebrafishSemantic proximity Read

Anderson or chylomicron retention disease: molecular impact of five mutations in the SAR1B gene on the structure and the functionality of Sar1b protein.Semantic proximity Read

Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi)Semantic proximity Read

The COPI coatomer influences LDL receptor activity, hepatic lipid storage, and apoB secretionSemantic proximity Read