Article

SAR1 paralogs differ biochemically in assembly of the COPII coat

2020-02-10

Abstract excerpt

<h4>ABSTRACT</h4> COPII-coated vesicles are the primary mediators of vesicular traffic from the ER to the Golgi apparatus. SAR1 is a small GTPase, which, upon GTP binding, recruits the other COPII proteins to the ER membrane. In mammals, there are two SAR1 paralogs which genetic data suggest may have distinct physiological roles, e.g. in lipoprotein secretion for SAR1B. We identified two clusters of amino acids t...

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Literature Corpus work: 73b6d330-95a4-559f-b1bc-8ed31dc98b7f
DOI: 10.1101/2020.02.09.940833

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