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Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo

30 Apr 2024

Abstract excerpt

Proteins carrying a signal peptide and/or a transmembrane domain enter the intracellular secretory pathway at the endoplasmic reticulum (ER) and are transported to the Golgi apparatus via COPII vesicles or tubules. SAR1 initiates COPII coat assembly by recruiting other coat proteins to the ER membrane. Mammalian genomes encode two SAR1 paralogs, SAR1A and SAR1B . While these paralogs exhibit ~90% amino acid...

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PMID: 38687799
DOI: 10.1073/pnas.2322164121

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