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A GRAB sensor reveals activity-dependent non-vesicular somatodendritic adenosine release

2020-05-05

Abstract excerpt

The purinergic signaling molecule adenosine (Ado) modulates many physiological and pathological brain functions,but its spatiotemporal release dynamics in the brain remains largely unknown. We developed a genetically encoded G PC R - A ctivation– B ased Ado sensor (GRAB Ado ) in which Ado-induced changes in the human A 2A receptor are reflected by fluorescence increases. This GRAB Ado revealed that neurona...

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Literature Corpus work
38620991-253e-555f-bea3-80a15f10170d
DOI
10.1101/2020.05.04.075564
Open publication

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A GRAB sensor reveals activity-dependent non-vesicular somatodendritic adenosine releaseDOI 10.1101/2020.05.04.075564
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