Article

Caspase isoforms in inflammasome activation

2020-01-01

Abstract excerpt

Inflammasomes are macromolecular signalling platforms composed of a receptor (for example NLRP3 or NLRC4), an adaptor (ASC) and effectors (caspases) that are thought to play critical roles in the host defence against microbial infections. Activation of inflammasomes leads to the processing of the pro-inflammatory cytokines pro-IL-1β and pro- IL-18 to their active form and cleavage of gasdermin D to induce pyroptos...

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Literature Corpus work: 9d60ef2b-15cf-5ce0-b401-63e4e1585756
DOI: 10.17863/cam.54927

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