Article

Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2 Phosphatase

2020-03-29

Abstract excerpt

<h4>ABSTRACT</h4> SH2 domain-containing tyrosine phosphatase 2 (SHP2), encoded by PTPN11 , plays a fundamental role in the modulation of several signaling pathways. Germline and somatic mutations in PTPN11 are associated with different rare diseases and hematologic malignancies, and recent studies have individuated SHP2 as a central node in oncogenesis and cancer drug resistance. SHP2 structure includes two Src...

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Literature Corpus work: 154ad548-44e0-5d49-98c6-861284cbfd5b
DOI: 10.1101/2020.03.27.012492

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