Article

Cancer-Causing Mutations Alter the Interplay Between Loop Dynamics and Catalysis in the Protein Tyrosine Phosphatases SHP-1 and SHP-2

2026-03-03

Abstract excerpt

The protein tyrosine phosphatases (PTPs) SHP-1 and SHP-2 play complex roles in a variety of signaling pathways, including those involved in cancers and other diseases, making them important drug targets. These two PTPs have superimposable active sites, but different biological functions in vivo , including opposing roles in cancer development. Unique to these PTPs is the presence of two tandem Src homology 2 (SH2...

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Literature Corpus work: 29670c71-bffe-5394-8586-8e52f2e6c492
DOI: 10.64898/2026.03.02.708844

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