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Article

Structural and functional effects of disease-causing amino acid substitutions affecting residues Ala72 and Glu76 of the protein tyrosine phosphatase SHP-2.

Proteins - 1 Mar 2007

Bocchinfuso Gianfranco, Stella Lorenzo, Martinelli Simone, Flex Elisabetta, Carta Claudio, Pantaleoni Francesca, Pispisa Basilio, Venanzi Mariano, Tartaglia Marco, Palleschi Antonio

Abstract excerpt

Mutations of the protein tyrosine phosphatase SHP-2 are implicated in human diseases, causing Noonan syndrome (NS) and related developmental disorders or contributing to leukemogenesis depending on the specific amino acid substitution involved. SHP-2 is composed by a catalytic (PTP) and two regulatory (N-SH2 and C-SH2) domains that bind to signaling partners and control the enzymatic activity by limiting the...

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PMID: 17177198
DOI: 10.1002/prot.21050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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