Article
Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains.
Molecular immunology - 1 Mar 2021
Iiyama Momoka, Numoto Nobutaka, Ogawa Shuhei, Kuroda Masataka, Morii Hisayuki, Abe Ryo, Ito Nobutoshi, Oda Masayuki
Abstract excerpt
During T-cell regulation, T-cell receptors and CD28 lead to signaling activation, while T-lymphocyte antigen 4 (CTLA-4) is known to lead to downregulation, similar to programmed cell death-1 (PD-1). In the cytoplasmic tails of CD28 and CTLA-4, phosphoinositide 3-kinase (PI3K) binds to the consensus sequence including phosphotyrosine via SH2 domains, N- and C-terminal SH2 domains (nSH2 and cSH2), of its regulatory...
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