Article

Atomistic ensemble of active SHP2 phosphatase

2023-05-05

Abstract excerpt

<h4>ABSTRACT</h4> SHP2 phosphatase plays an important role in regulating several intracellular signaling pathways. Pathogenic mutations of SHP2 cause developmental disorders and are linked to hematological malignancies and cancer. SHP2 comprises two tandemly-arranged SH2 domains, a catalytic PTP domain, and a disordered C-terminal tail. Under physiological, non-stimulating conditions, the catalytic site of PTP is...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0a96d13b-4025-51d6-aeb0-d14014cbe9c9
DOI: 10.1101/2023.05.04.539460

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Atomistic ensemble of active SHP2 phosphataseDOI 10.1101/2023.05.04.539460Read

Atomistic ensemble of active SHP2 phosphatase.Semantic proximity Read

The pathogenic E139D mutation stabilizes a non-canonical active state of the multi-domain phosphatase SHP2Semantic proximity Read

An allosteric interaction controls the activation mechanism of SHP2 tyrosine phosphataseSemantic proximity Read

Phosphatase SHP2 pathogenic mutations enhance activity by altering conformational samplingSemantic proximity Read

The pathogenic E139D mutation stabilizes a non-canonical active state of the multi-domain phosphatase SHP2.Semantic proximity Read

Phosphatase SHP2 pathogenic mutations enhance activity by altering conformational sampling.Semantic proximity Read

E76K Mutation Promotes SHP2 Activation by Rewiring Allosteric Networks That Drives Conformational Transitions.Semantic proximity Read

Structural and functional effects of disease-causing amino acid substitutions affecting residues Ala72 and Glu76 of the protein tyrosine phosphatase SHP-2.Semantic proximity Read

An allosteric interaction controls the activation mechanism of SHP2 tyrosine phosphatase.Semantic proximity Read

A novel partially open state of SHP2 points to a "multiple gear" regulation mechanism.Semantic proximity Read

SHP2 clinical phenotype, cancer, or RASopathies, can be predicted by mutant conformational propensities.Semantic proximity Read

Targeting SHP2 Cryptic Allosteric Sites for Effective Cancer Therapy.Semantic proximity Read