Article

Replicating without stress: a dengue replicon model reveals distinct host rewiring to accommodate persistence

2025-09-27

Abstract excerpt

<h4>Summary</h4> Self-replicating viral RNAs, or replicons, are widely used to study virus-host interactions and screen antiviral compounds, yet their ability to model persistent infection and host adaptation remains poorly understood. Here, we characterize a stable subgenomic dengue virus serotype 2 (DENV2) replicon (DENV2-rep) that supports long-term viral RNA replication in human hepatoma cells without trigger...

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Literature Corpus work: 1548662b-0d74-5b0f-85c4-456d66f542cc
DOI: 10.1101/2025.09.27.678963

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