Article

Zika virus remodels and hijacks IGF2BP2 ribonucleoprotein complex to promote viral replication organelle biogenesis

2023-12-11

Abstract excerpt

<h4>SUMMARY</h4> Zika virus (ZIKV) infection causes significant human disease that, with no approved treatment or vaccine, constitutes a major public health concern. Its life cycle entirely relies on the cytoplasmic fate of the viral RNA genome (vRNA) through a fine-tuned equilibrium between vRNA translation, replication and packaging into new virions, all within virus-induced replication organelles (vRO). In thi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 56c91f88-9ac4-5e5a-a186-300a85ff2cc2
DOI: 10.1101/2023.12.08.570783

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Zika virus remodels and hijacks IGF2BP2 ribonucleoprotein complex to promote viral replication organelle biogenesisDOI 10.1101/2023.12.08.570783Read

Host cytoskeletal vimentin serves as a structural organizer and an RNA-binding protein regulator to facilitate Zika viral replicationSemantic proximity Read

Host cytoskeletal vimentin serves as a structural organizer and an RNA-binding protein regulator to facilitate Zika viral replicationSemantic proximity Read

Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNASemantic proximity Read

Zika virus NS3 drives the assembly of a viroplasm-like structureSemantic proximity Read

Zika Virus NS2A-Mediated Virion Assembly.Semantic proximity Read

Crosstalk between RNA Metabolism and Cellular Stress Responses during Zika Virus ReplicationSemantic proximity Read

Molecular Insights into the Flavivirus Replication ComplexSemantic proximity Read

Dysregulation of Long Non-coding RNA (lncRNA) Genes and Predicted lncRNA-Protein Interactions during Zika Virus InfectionSemantic proximity Read

RPLP1 and RPLP2 Are Essential Flavivirus Host Factors That Promote Early Viral Protein AccumulationSemantic proximity Read

PTBP1 is upregulated by Zika virus infection <i>via</i> HIF-1α signal and hijacks NS1 protein to induce NS1 degradation to restrain viral replicationSemantic proximity Read

Functional RNA during Zika virus infectionSemantic proximity Read

Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesisSemantic proximity Read