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Dual role of Human antigen R in Dengue virus infection: suppression of replication and promotion of cap-independent translation

2025-07-24

Abstract excerpt

Host RNA-binding proteins (RBPs) play a pivotal role in regulating dengue virus (DENV) translation and replication through interactions with untranslated regions (UTRs) of viral RNA. We investigated host proteins associated with detergent-resistant membranes (DRMs) of the DENV replication complex and identified Human antigen R (HuR) as a key RBP enriched in the DRM. HuR was found to negatively regulate DENV replic...

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Literature Corpus work
a86e7bff-7e3f-5883-890b-818fba75e3dd
DOI
10.1101/2025.07.24.666571
Open publication

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Dual role of Human antigen R in Dengue virus infection: suppression of replication and promotion of cap-independent translationDOI 10.1101/2025.07.24.666571
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