Article

Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elements

2021-02-16

Abstract excerpt

<h4>ABSTRACT</h4> Transcriptional profiling provides global snapshots of virus-mediated cellular reprogramming, which can simultaneously encompass pro- and antiviral components. To determine early transcriptional signatures associated with HCV infection of authentic target cells, we performed ex vivo infections of adult primary human hepatocytes (PHHs) from seven donors. Longitudinal sampling identified minimal g...

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Literature Corpus work: 11895a11-3f07-51d4-9255-f5de252ce627
DOI: 10.1101/2021.02.12.431054

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