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Flaviviridae Replication Organelles: Oh, What a Tangled Web We Weave

6 Nov 2015

Abstract excerpt

Replication of positive-strand RNA viruses occurs in tight association with reorganized host cell membranes. In a concerted fashion, viral and cellular factors generate distinct organelle-like structures, designated viral replication factories. These virus-induced compartments promote highly efficient genome replication, allow spatiotemporal coordination of the different steps of the viral replication cycle, and...

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PMID: 26958917
DOI: 10.1146/annurev-virology-100114-055007

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