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Replication Vesicles are Load- and Choke-Points in the Hepatitis C Virus Lifecycle

22 Aug 2013

Abstract excerpt

Hepatitis C virus (HCV) infection develops into chronicity in 80% of all patients, characterized by persistent low-level replication. To understand how the virus establishes its tightly controlled intracellular RNA replication cycle, we developed the first detailed mathematical model of the initial dynamic phase of the intracellular HCV RNA replication. We therefore quantitatively measured viral RNA and protein...

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PMID: 23990783
DOI: 10.1371/journal.ppat.1003561

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