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High-Throughput Targeted Drug Screening for NF1-associated High-Grade Gliomas with ATRX Deficiency

2024-12-17

Abstract excerpt

Neurofibromatosis type 1 (NF1)-associated high-grade gliomas (HGGs) harboring ATRX mutations exhibit an aggressive clinical phenotype, driven by heightened genomic instability and metabolic reprogramming. Existing therapies, including chemotherapy and radiotherapy, are limited by resistance mechanisms and formation of secondary malignancy, underscoring the need for novel therapeutic strategies. Here, we report the...

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Literature Corpus work
0b8078d0-5d58-5bd0-bb1f-9f98abc437e0
DOI
10.1101/2024.12.14.628525
Open publication

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High-Throughput Targeted Drug Screening for NF1-associated High-Grade Gliomas with ATRX DeficiencyDOI 10.1101/2024.12.14.628525
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