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<i>In vivo</i> CRISPR screening identifies <i>NF1/RASA1/TP53</i> co-mutations and downstream MEK signaling as a common key mechanism of sinonasal tumorigenesis

2025-05-23

Abstract excerpt

Genomic alterations driving tumorigenesis in sinonasal malignancies remain largely unexplored. Here, we perform an in vivo loss-of-function screen using a pooled custom single-guide library delivered to the sinonasal cavity by adeno-associated virus vector to identify cancer driver genes across diverse sinonasal malignancies. This approach yielded sinonasal malignancies with diverse histologies, including sinonas...

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Identifiers and source

Literature Corpus work
26a116b7-2cce-5c9d-9898-572c47decead
DOI
10.1101/2025.05.19.654661
Open publication

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<i>In vivo</i> CRISPR screening identifies <i>NF1/RASA1/TP53</i> co-mutations and downstream MEK signaling as a common key mechanism of sinonasal tumorigenesisDOI 10.1101/2025.05.19.654661
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