Article

The assessment of therapeutic autophagy inhibition in NF1 mutated tumor cells

2024-11-15

Abstract excerpt

MAPK pathway activation is found across central nervous system tumors. Neurofibromin 1 (NF1) protein is a GTPase-activating protein and tumor suppressor that negatively regulates RAS protein activity. A NF1 loss of function mutation results in MAPK pathway upregulation and is associated with pediatric gliomas. We previously demonstrated autophagy inhibition improves tumor response to BRAF inhibition. Here we inves...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 264b7f12-c3e4-5425-9e06-03370a6d3dd1
DOI: 10.1101/2024.11.12.623325

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The assessment of therapeutic autophagy inhibition in NF1 mutated tumor cellsDOI 10.1101/2024.11.12.623325Read

Inhibition of autophagy as a novel therapy for the treatment of neurofibromatosis type 1 tumorsSemantic proximity Read

Dual inhibition of SHP2 and autophagy suppresses NF1-associated Malignant Peripheral Nerve Sheath TumorsSemantic proximity Read

Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers.Semantic proximity Read

Defining Key Signaling Nodes and Therapeutic Biomarkers in <i>NF1</i> -Mutant CancersSemantic proximity Read

The Neurofibromatosis Type 1 Tumor Suppressor Controls Cell Growth by Regulating Signal Transducer and Activator of Transcription-3 Activity <i>In vitro</i> and <i>In vivo</i>Semantic proximity Read

Systematic analysis uncovers SYK dependency in NF1 <sup>LoF</sup> melanoma cellsSemantic proximity Read

New Model Systems and the Development of Targeted Therapies for the Treatment of Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors.Semantic proximity Read

Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumorsSemantic proximity Read

Effect of early-stage autophagy inhibition in BRAFV600E autophagy-dependent brain tumor cellsSemantic proximity Read

Nf1-Mutant Tumors Undergo Transcriptome and Kinome Remodeling after Inhibition of either mTOR or MEK.Semantic proximity Read

Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of neurofibromatosis type 1Semantic proximity Read

MEK inhibition enhances the antitumor effect of radiation therapy in <i>NF1</i> -deficient glioblastomaSemantic proximity Read