Article

A p53 Intron-Encoded lncRNA and the Maintenance of the Proliferative Undifferentiated State of Myeloid Leukemia Cells

2024-07-17

Abstract excerpt

Acute myeloid leukemias are characterized by genetic alterations that lead to a complete or partial block at various stages of myeloid differentiation, leading to continual proliferation of myeloid progenitor cells. These alterations can include a well-documented chromosomal translocation that leads to the synthesis of the PML-retinoic acid receptor fusion protein that leads to a block in differentiation and the a...

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Literature Corpus work: 15147b5b-f8d0-5155-aa6f-46a5196b93f1
DOI: 10.20944/preprints202407.1372.v1

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