Article
p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia.
Blood - 19 Jan 2017
Zhang Jingfang, Kong Guangyao, Rajagopalan Adhithi, Lu Li, Song Jingming, Hussaini Mohamed, Zhang Xinmin, Ranheim Erik A, Liu Yangang, Wang Jinyong, Gao Xin, Chang Yuan-I, Johnson Kirby D, Zhou Yun, Yang David, Bhatnagar Bhavana, Lucas David M, Bresnick Emery H, Zhong Xuehua, Padron Eric, Zhang Jing
Abstract excerpt
Somatic mutations in TP53 and NRAS are associated with transformation of human chronic myeloid diseases to acute myeloid leukemia (AML). Here, we report that concurrent RAS pathway and TP53 mutations are identified in a subset of AML patients and confer an inferior overall survival. To further investigate the genetic interaction between p53 loss and endogenous NrasG12D/+ in AML, we generated conditional...
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