Article

Prominin-1 null Xenopus laevis develop subretinal drusenoid-like deposits, cone-rod dystrophy, and RPE atrophy

2024-06-03

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the PROMININ-1 ( PROM1) gene are associated with inherited, non-syndromic vision loss. Here, we used CRISPR/Cas9 to induce truncating prom1 -null mutations in Xenopus laevis to create a disease model. We then tracked progression of retinal degeneration in these animals from the ages of 6 weeks to 3 years old. We found that retinal degeneration caused by prom1 -null is age-depen...

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Literature Corpus work: 15091063-9552-5548-a46a-2f78031a1f80
DOI: 10.1101/2024.06.03.597229

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