Article
Genetic background and light-dependent progression of photoreceptor cell degeneration in Prominin-1 knockout mice.
Investigative ophthalmology & visual science - 20 Nov 2014
Dellett Margaret, Sasai Noriaki, Nishide Kenji, Becker Silke, Papadaki Vasiliki, Limb G Astrid, Moore Anthony T, Kondo Toru, Ohnuma Shin-Ichi
Abstract excerpt
PURPOSE: Mutations in the Prominin-1 (Prom1) gene are known to cause retinitis pigmentosa and Stargardt disease, both of which are associated with progressive photoreceptor cell death. There are no effective therapies for either disorder. The aim of this study was to investigate the mechanism of the retinal degeneration in Prom1-deficient mouse models. METHODS: We constructed Prom1 knockout mice with two distinct...
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