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Article

Loss of Prom1 impairs autophagy and promotes epithelial‐mesenchymal transition in mouse retinal pigment epithelial cells

23 Aug 2023

Abstract excerpt

Mutations in the Prominin-1 (Prom1) gene disrupt photoreceptor disk morphogenesis, leading to macular dystrophies. We have shown that human retinal pigment epithelial (RPE) homeostasis is under the control of Prom1-dependent autophagy, demonstrating that Prom1 plays different roles in the photoreceptors and RPE. It is unclear if retinal and macular degeneration caused by the loss of Prom1 function is a...

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PMID: 37610047
DOI: 10.1002/jcp.31094

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