Article
Acquisition of stem associated-features on metastatic osteosarcoma cells and their functional effects on mesenchymal stem cells.
Biochimica et biophysica acta. General subjects - 1 Apr 2020
Álvarez Matías Valenzuela, Gutiérrez Luciana M, Auzmendi Jerónimo, Correa Alejandro, Lazarowski Alberto, Bolontrade Marcela F
Abstract excerpt
BACKGROUND: Osteosarcoma (OS) is the most frequent malignant bone tumor, affecting predominantly children and young adults. Metastases are a major clinical challenge in OS. In this context, 20% of OS patients are diagnosed with metastatic OS, but near 80% of all OS patients could present non-detectable micrometastases at the moment of diagnosis. METHODS: Osteogenic differentiation; doxorubicin exclusion assay;...
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