Metastatic niche functions and therapeutic opportunities.

Abstract excerpt

Metastasis is an inefficient process, especially during colonization at a distant organ. This bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of metastases. Here, we classify the common functions of different metastatic niches: anchorage, survival support, protection from external insults, licensing proliferation and outgrowth. We highlight the emerging role of the metastatic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Stem Cell Niche
• Share to Cell Communication
• Share to Cell Plasticity