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Article

Bone marrow-derived mesenchymal stem cells promote invasiveness and transendothelial migration of osteosarcoma cells via a mesenchymal to amoeboid transition.

Molecular oncology - 1 May 2018

Pietrovito Laura, Leo Angela, Gori Valentina, Lulli Matteo, Parri Matteo, Becherucci Valentina, Piccini Luisa, Bambi Franco, Taddei Maria Letizia, Chiarugi Paola

Abstract excerpt

There is growing evidence to suggest that bone marrow-derived mesenchymal stem cells (BM-MSCs) are key players in tumour stroma. Here, we investigated the cross-talk between BM-MSCs and osteosarcoma (OS) cells. We revealed a strong tropism of BM-MSCs towards these tumour cells and identified monocyte chemoattractant protein (MCP)-1, growth-regulated oncogene (GRO)-α and transforming growth factor (TGF)-β1 as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29517849
DOI: 10.1002/1878-0261.12189
PMCID: PMC5928379

Genes

MSC

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