Article

Hydroxychloroquine increased psychiatric-like behaviors and disrupted the expression of related genes in the mouse brain

2020-09-28

Abstract excerpt

Hydroxychloroquine (HCQ), which has been proposed as a therapeutic or prophylactic drug for SARS-COV-2, has been administered to thousands of individuals with varying efficacy; however, our understanding of its adverse effects is insufficient. It was reported that HCQ induced psychiatric symptoms in a few patients with autoimmune diseases, but it is still uncertain whether HCQ poses a risk to mental health. Theref...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 14cf90b9-b7d1-5a75-82eb-bc9b28fbbf1e
DOI: 10.1101/2020.09.27.316158

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest

Hydroxychloroquine increased psychiatric-like behaviors and disrupted the expression of related genes in the mouse brainDOI 10.1101/2020.09.27.316158Read

Hydroxychloroquine inhibits trained immunity – implications for COVID-19Semantic proximity Read

Molecular effects and retinopathy induced by hydroxychloroquine during SARS-CoV-2 therapy: Role of CYP450 isoforms and epigenetic modulationsSemantic proximity Read

Risk of depression, suicidal ideation, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multi-national network cohort studySemantic proximity Read

5-aminoisoquinolinone attenuates social behavior deficits and immune abnormalities in the BTBR T+ Itpr3tf/J mouse model for autism.Semantic proximity Read

TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) induces depression-like phenotype.Semantic proximity Read

Trypanosoma cruzi-induced depressive-like behavior is independent of meningoencephalitis but responsive to parasiticide and TNF-targeted therapeutic interventions.Semantic proximity Read

Parallel Effects of Methamphetamine on Anxiety and CCL3 in Humans and a Genetic Mouse Model of High Methamphetamine Intake.Semantic proximity Read

The haze around pharmacokinetics of hydroxychloroquineSemantic proximity Read

Resveratrol prevents arsenic-induced depression-like phenotypes via modulation of BDNF signaling.Semantic proximity Read

Rare-earth nanoparticles induce depression, anxiety-like behavior, and memory impairment in miceSemantic proximity Read

Bacillus Calmette-Guérin vaccine induces a selective serotonin reuptake inhibitor (SSRI)-resistant depression like phenotype in mice.Semantic proximity Read