Article
Parallel Effects of Methamphetamine on Anxiety and CCL3 in Humans and a Genetic Mouse Model of High Methamphetamine Intake.
Neuropsychobiology - 1 Jan 2017
Huckans Marilyn, Wilhelm Clare J, Phillips Tamara J, Huang Elaine T, Hudson Rebekah, Loftis Jennifer M
Abstract excerpt
BACKGROUND: Methamphetamine (MA) abuse causes immune dysfunction and neuropsychiatric impairment. The mechanisms underlying these deficits remain unidentified. METHODS: The effects of MA on anxiety-like behavior and immune function were investigated in mice selectively bred to voluntarily consume high amounts of MA [i.e., MA high drinking (MAHDR) mice]. MA (or saline) was administered to mice using a chronic...
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