Article
Bacillus Calmette-Guérin vaccine induces a selective serotonin reuptake inhibitor (SSRI)-resistant depression like phenotype in mice.
Brain, behavior, and immunity - 1 Nov 2014
Vijaya Kumar K, Rudra Anjuman, Sreedhara M V, Siva Subramani T, Prasad Durga Shiva, Das Manish Lal, Murugesan Senthil, Yadav Rajbharan, Trivedi Ravi Kumar, Louis Justin V, Li Yu-Wen, Bristow Linda J, Naidu Pattipati S, Vikramadithyan Reeba Kannimel
Abstract excerpt
Preclinical studies have shown that administration of Bacillus Calmette-Guérin (BCG) vaccine induces depression-like behaviors in mice; however, the effect of antidepressant drug treatment has not been reported earlier. In the present study, we induced depression-like behavior by administering BCG vaccine to BALB/c mice. BCG treatment produced robust serum sickness as shown by a decrease in body weight, reduced...
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