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Article

Trypanosoma cruzi-induced depressive-like behavior is independent of meningoencephalitis but responsive to parasiticide and TNF-targeted therapeutic interventions.

Brain, behavior, and immunity - 1 Oct 2012

Vilar-Pereira Glaucia, Silva Andrea Alice da, Pereira Isabela Resende, Silva Rafael Rodrigues, Moreira Otacílio Cruz, de Almeida Luciana Rodrigues, de Souza Amanda Santos, Rocha Monica Santos, Lannes-Vieira Joseli

Abstract excerpt

Inflammatory cytokines and microbe-borne immunostimulators have emerged as triggers of depressive behavior. Behavioral alterations affect patients chronically infected by the parasite Trypanosoma cruzi. We have previously shown that C3H/He mice present acute phase-restricted meningoencephalitis with persistent central nervous system (CNS) parasitism, whereas C57BL/6 mice are resistant to T. cruzi-induced CNS...

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PMID: 22841695
DOI: 10.1016/j.bbi.2012.07.009

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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