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Article

TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) induces depression-like phenotype.

Neurotoxicology - 1 Jul 2024

Debler Roanna A, Gallegos Paula L, Ojeda Alexandra C, Perttula Andrea M, Lucio Ashley, Chapkin Robert S, Safe Stephen, Eitan Shoshana

Abstract excerpt

The etiology of major depressive disorder (MDD) remains poorly understood. Our previous studies suggest a role for the aryl hydrocarbon receptor (AhR) in depression. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a toxic environmental contaminant, with a high AhR binding affinity, and an established benchmark for assessing AhR activity. Therefore, this study examined the effect of TCDD on depression-like...

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Identifiers

PMID: 38838945
DOI: 10.1016/j.neuro.2024.05.010
PMCID: PMC11288769

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