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Article

5-aminoisoquinolinone attenuates social behavior deficits and immune abnormalities in the BTBR T+ Itpr3tf/J mouse model for autism.

Pharmacology, biochemistry, and behavior - 1 Feb 2020

Ahmad Sheikh F, Ansari Mushtaq A, Nadeem Ahmed, Bakheet Saleh A, Alqahtani Faleh, Alhoshani Ali R, Alasmari Fawaz, Alsaleh Nasser B, Attia Sabry M

Abstract excerpt

Autism spectrum disorder (ASD) is diagnosed by core symptoms including impaired social communication and the presence of repetitive and stereotypical behaviors. There is also evidence for immune dysfunction in individuals with ASD, but it is a disease that is still insufficiently controlled by current treatment strategies. The use of 5-aminoisoquinolinone (5-AIQ) ameliorates several immune-mediated symptoms...

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PMID: 31982447
DOI: 10.1016/j.pbb.2020.172859

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