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Article

Resveratrol prevents arsenic-induced depression-like phenotypes via modulation of BDNF signaling.

Behavioural brain research - 5 Mar 2026

Kharazmi Mohaddeseh, Khalili Tayyebeh, Dehghan-Shasaltaneh Marzieh, Bahari Abbas, Ebrahimi-Ghiri Mohaddeseh

Abstract excerpt

Growing evidence suggests that resveratrol possesses neuroprotective properties against arsenic toxicity. This study investigated whether resveratrol could ameliorate arsenic-induced depression-like behaviors in male Naval Medical Research Institute (NMRI) mice and explored potential molecular mechanisms. Mice were exposed to arsenic (50 mg/L in drinking water) for 4 weeks and treated with resveratrol (10 or...

Topics

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Antidepressive Agents
Arsenic
Behavior, Animal
Brain
Brain-Derived Neurotrophic Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cyclic AMP Response Element-Binding Protein

Source

Identifiers

PMID: 41380913
DOI: 10.1016/j.bbr.2025.115988

Genes

FST
SST
TST
BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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